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Principal ROS produced by inflammatory cells include superoxide (O 2 ), hydroxyl radical (OH), hydroperoxyl radical (HO 2 ), nitric oxide (NO), and singlet oxygen ( 1 O 2 ) ( 3 Clinical studies in companion animals Canine chronic inflammatory enteropathies (CIE) refer to a group of intestinal disorders characterized by persistent or recurrent gastrointestinal (GI) signs and variable intestinal inflammation ( There are few clinical studies evaluating the role of OS in dogs with CIE

The findings from these studies align with the biophilia hypothesis, which argues that humans naturally prefer nature because we evolved in it

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As is known, anti-GFAP is an astrocyte marker and anti-Iba-1 is a microglia marker